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Andris Dišlers , Dr. biol
Senior researcher
Phone: +371 67808213
E-mail:
dishlers@biomed.lu.lv
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A. Dishlers lab
Projects
Characterization of DNA bacteriophages isolated from the insect intestine microflora
Technology to obtain high quality virus-like nanostructures based on HBV core-antigen
Development of the prototype of new universal Hepatitis B recombinant vaccine
Recombinant vaccines - technologization of virus-like particles
Combined application of E. coli, S. cerevisiae and P. Pastoris expression systems for producing of functional recombinant proteins
Comparison, analysis and evaluation of bacteral and yeast expression systems
Publications
International
The chaperone dynein LL1 mediates cytoplasmic transport of empty and mature hepatitis B virus capsids Osseman Q, Gallucci L, Au S, Cazenave C, Berdance E, Blondot ML, Cassany A,Bégu D, Ragues J, Aknin C,, I Sominska, A Dišlers, Rabe B, Anderson F, Panté N, Kann M , J Hepatol., Nov 4. [Epub ahead of print] , 2017
Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice Backes S, Jäger C, Dembek CJ, Kosinska AD, Bauer T, Stephan AS, A Dišlers, Mutwiri G, Busch DH, Babiuk LA, Gasteiger G, Protzer U. , Vaccine. 2016 Feb 10;34(7):923-32 , 2016
The True Story and Advantages of RNA Phage Capsids as Nanotools P Pumpēns, R Renhofa, A Dišlers, T Kozlovska, V Ose-Klinklāva, Pushko, P., K Tārs, E Grēns, Bachmann, M.F. , Intervirology, pp. 74-110 , 2016
The Hepatitis B Virus Core Variants that Expose Foreign C-Terminal Insertions on the Outer Surface of Virus-Like Particles A Dišlers, D Skrastiņa, R Renhofa, I Petrovskis, V Ose-Klinklāva, I Liekniņa, J Jansons, P Pumpēns, I Sominska , Molecular Biotechnology, 57 (11-12), pp. 1038-1049 , 2015
Plasmid Dimerization Increases the Production of Hepatitis B Core Particles in E. coli. I Bērza, A Dišlers, I Petrovskis, K Tārs, A Kazāks , Biotechnology and Bioprocess Engineering, Sep Vol 18, Issue 5, pp 850-857 , 2013
A VLP library of C-terminally truncated Hepatitis B core proteins: correlation of RNA encapsidation with a Th1/Th2 switch in the immune responses of mice. I Sominska, D Skrastiņa, I Petrovskis, A Dišlers, I Bērza, M Mihailova, J Jansons, I Akopjana, I Stahovska, D Dreiliņa, V Ose-Klinklāva, P Pumpēns , PLoS One. Sep 23;8(9):e75938. , 2013
Highly efficient production of phosphorylated hepatitis B core particles in yeast Pichia pastoris. J Freivalds, A Dišlers, V Ose-Klinklāva, P Pumpēns, K Tārs, A Kazāks , Protein Expr Purif. 75(2):218-24. , 2011
Genome Structure of Caulobacter Phage phiCb5 A Kazāks, T Kazāka, J Rūmnieks, A Dišlers, K Tārs , J Virol. 85:4628-31. , 2011
Construction and immunological evaluation of multivalent hepatitis B virus (HBV) core virus-like particles carrying HBV and HCV epitopes. I Sominska, D Skrastiņa, A Dišlers, Vasiljev D, M Mihailova, V Ose-Klinklāva, D Dreiliņa, P Pumpēns , Clin Vaccine Immunol. 17(6):1027-33 , 2010
The structure of bacteriophage phiCb5 reveals a role of the RNA genome and metal ions in particle stability and assembly. Plevka P, A Kazāks, T Kazāka, S Koteloviča, A Dišlers, Liljas L, K Tārs , J Mol Biol. 391(3):635-47 , 2009
Assembly of mixed rod-like and spherical particles from group I and II RNA bacteriophage coat proteins J Rūmnieks, V Ose-Klinklāva, K Tārs, A Dišlers, A Strods, I Cielēns, R Renhofa , Virology 391(2):187-94 , 2009
Assembly of bacteriophage Qβ virus-like particles in yeast Saccharomyces cerevisiae and Pichia pastoris. J Freivalds, A Dišlers, V Ose-Klinklāva, D Skrastiņa, I Cielēns, P Pumpēns, Sasnauskas K, A Kazāks , J Biotechnol. 123(3):297-303. , 2006
Efficient homologous prime-boost strategies for T cell vaccination based on virus-like particles Schwarz K, Meijerink E, Speiser DE, Tissot AC, I Cielēns, R Renhofa, A Dišlers, P Pumpēns, Bachmann MF , Eur J Immunol. 35(3):816-21. , 2005
Mosaic hepatitis B virus core particles presenting the complete preS sequence of the viral envelope on their surface. A Kazāks, Borisova G, Cvetkova S, Kovalevska L, V Ose-Klinklāva, I Sominska, P Pumpēns, D Skrastiņa, A Dišlers , J Gen Virol. 85(Pt 9):2665-70. , 2004
Mosaic particles formed by wild-type hepatitis B virus core protein and its deletion variants consist of both homo- and heterodimers A Kazāks, A Dišlers, P Pumpēns, Ulrich R, Kruger DH, Meisel H , FEBS Lett 549(1-3):157-62. , 2003
Local
Display vectors. I. Hepatitis B core particle as a display moiety. Borisova G, Borschukova O, D Skrastiņa, Mezule G, A Dišlers, I Petrovskis, V Ose-Klinklāva, Gusars I, P Pumpēns, E Grēns , Proc. Latvian Acad. Sci. 51:1-7 , 1997
Display vectors. II. Recombinant capsid of RNA bacteriophage Qb as a display moiety. T Kozlovska, I Cielēns, I Vasiļjeva, Bundule M, Strelnikova A, A Kazāks, A Dišlers, D Dreiliņa, V Ose-Klinklāva, Gusars I, P Pumpēns , Proc. Latvian Acad. Sci. 51: 8-12 , 1997
Patents
Paņēmiens tukšu un ar nukleīnskābēm pildītu hepatīta B vīrusa core-proteīna kapsīdu iegūšanai I Liekniņa, I Petrovskis, I Sominska, J Bogans, I Akopjana, P Pumpēns, A Dišlers , LR patenta pieteikuma nr. P-14-81 , 2015
COUPLING OF BORRELIAL PROTEIN BB0689 TO VIRUS-LIKE PARTICLES FOR GENERATION OF LYME DISEASE VACCINE K Tārs, I Petrovskis, A Dišlers, D Skrastiņa, A Zeltiņš, K Brangulis, S Koteloviča , Europena Patent Office, Application number EP15182845.6 , 2015
Paņēmiens izvēlēta materiāla piešūšanai HBV core proteīna veidotajām nanodaļiņām R Renhofa, A Kazāks, A Dišlers, L Jackeviča, V Ose-Klinklāva, P Pumpēns , LR patents LV 15033 , 2014
Ekspresijas sistēma HBc-preS1 vīrusveidīgo daļiņu iegūšanai A Dišlers, I Petrovskis, I Liekniņa, I Bērza, J Bogans, I Akopjana, I Sominska, P Pumpēns , LR patents LV 14945 , 2013
Magnētisko nanodaļiņu iepakošana HBV core proteīna veidotajās kapsīdās. R Renhofa, A Dišlers, Ozols J, V Ose-Klinklāva, P Pumpēns , LR patents LV 14304 B , 2009
Rekombinants rauga Pichia pastoris celms cilvēka hepatīta B vīrusa (subtips ayw) nukleokapsīdu iegūšanai. A Kazāks, J Freivalds, P Pumpēns, A Dišlers , LR patents Nr. 13740 , 2008
Ekspresijas sistēma rekombinanto vīrusveidīgo daļiņu iegūšanai A Dišlers, I Sominska, A Kazāks, I Petrovskis, Zariņa I , LR patents Nr. 13587 , 2008
Conference thesis
Bcore as a most succesful VLP carrier A Dišlers , Virus-like particles (VLPs)as vaccines, vectors and adjuvants, Annecy, Francija , 2014
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Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".