About us

Groups

• D. Fridmanis lab

Projects

• Gut microbiota composition in relation to extrinsic factors and health status in infants and toddlers: prospective analysis of faecal microbiota composition by meategenomic sequencing in children up to 36 months of age
• Characterization and dynamics of seed-associated microbiome in weed soil seed-bank
• Strengthening GPCR functional research through improvement of novel peptidic ligand identification system
• Association of human intestinal and blood microbiome composition with general state of health and mortality within population of Latvia
• Characterization of general and mastitis susceptibility genetic background for Latvia’s (indigenous) local breeds of ruminants
• Long term effects of H.pylori eradication on Gastro intestinal tract microbiome and development of screening system for detection of extended-spectrum beta-lactamase coding genes within feces samples
• Development of orphan G-protein coupled receptor peptidic ligand identification system
• Molecular Structure of Melanocortin receptors and their accessory proteins

Publications

• International

• Association of metformin administration with gut microbiome dysbiosis in healthy volunteers I Elbere, I Kalniņa, I Silamiķelis, Konrade, I, L Zaharenko, L., Sekace, I Radoviča-Spalviņa, D Fridmanis, D Gudrā, V Pīrāgs, J Kloviņš , PLoS ONE, 13 (9), art. no. e0204317. PMID: 30261008 , 2018
• A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies D Gudrā, Shoaie, S.,, D Fridmanis, J Kloviņš, Wefer, H., I Silamiķelis, R Pečulis, I Kalniņa, I Elbere, I Radoviča-Spalviņa, Hultcrantz, R., Skenders, G., Leja, M., Engstrand, L , Gut, . Article in Press. PMID: 30242040 , 2018
• Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals. I Elbere, I Silamiķelis, M Ustinova, I Kalniņa, L Zaharenko, R Pečulis, Konrade I, Ciuculete DM, Zhukovsky C,, D Gudrā, I Radoviča-Spalviņa, D Fridmanis, Pirags V, Schiöth HB, J Kloviņš , Clinical Epigenetics , 2018
• What do we know about underlying molecular mechanisms? D Fridmanis, A Roga, J Kloviņš, ACTH receptor (MC2R) specificity , Frontiers in Endocrinology, 8 (FEB), art. no. 13 , 2017
• Microbiome symbionts and diet diversity incur costs on the immune system of insect larvae Krams IA, Kecko S, Jõers P, Trakimas G, Elferts D, Krams R, Luoto S, Rantala MJ,, I Iņaškina, D Gudrā, D Fridmanis, Contreras-Garduño J, Grantiņa-Ieviņa L, Krama T. , Journal of Experimental Biology, 220 (22), pp. 4204-4212. , 2017
• The effects of ibuprofen on activated sludge: Shift in bacterial community structure and resistance to ciprofloxacin Davids, M.,, D Gudrā, I Radoviča-Spalviņa, D Fridmanis, Bartkevics, V., Muter, O. , Journal of Hazardous Materials, 340, pp. 291-299. , 2017
• Removal of pharmaceuticals from municipal wastewaters at laboratory scale by treatment with activated sludge and biostimulation Muter, O., Perkons, I., Selga, T., Berzins, A.,, D Gudrā, I Radoviča-Spalviņa, D Fridmanis, Bartkevics, V , Science of the Total Environment, 584-585, pp. 402-413. , 2017
• What influences the composition of fungi in wheat grains? Bankina, B., Bimšteine, G., Neusa-Luca, I.,, A Roga, D Fridmanis , Acta Agrobotanica, 70 (4), art. no. 1726. PMID , 2017
• Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients L Zaharenko, I Kalniņa, Geldnere, K., Konrade, I., Grinberga, S., Židzik ,J., Javorský, M., Lejnieks, A., L Ņikitina-Zaķe, D Fridmanis, R Pečulis, I Radoviča-Spalviņa, Hartmane, D., Pugovics, O., Tkáč, I., Klimčáková, L., V Pīrāgs, J Kloviņš , European Journal of Endocrinology , 2016
• Evaluation of massive parallel sequencing as a diagnostic tool for familial hypercholesterolemia I Radoviča-Spalviņa, Berzins R, Latkovskis G, D Fridmanis, L Ņikitina-Zaķe, Ventins K, Ozola G, Erglis A, J Kloviņš , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 69 (1-2), pp. 1-7 , 2015
• Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL-C levels in a latvian population I Radoviča-Spalviņa, Latkovskis, G.,, I Silamiķelis, D Fridmanis, I Elbere, Ventins, K., Ozola, G., Erglis, A., J Kloviņš , BMC Medical Genetics, 16 (1), art. no. 86. , 2015
• Replacement of short segments within transmembrane domains of MC2R disrupts retention signal. D Fridmanis, R Petrovska, D Pjanova, Schiöth HB, J Kloviņš , J Mol Endocrinol. 53(2):201-15. , 2014
• The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity V Rovīte, R Petrovska, I Vaivade, I Kalniņa, D Fridmanis, L Zaharenko, R Pečulis, V Pīrāgs, Schioth HB, J Kloviņš , Mol Biol Rep. 41(3):1491-500 , 2014
• Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population. I Radoviča-Spalviņa, D Fridmanis, I Silamiķelis, L Ņikitina-Zaķe, J Kloviņš , Meta Gene. 2:565-78 , 2014
• Massive paralel sequencing in hypercholesterolemic patients of Latvia I Radoviča-Spalviņa, R.Berziņš, D.Silava, I Silamiķelis, D Fridmanis, J Kloviņš , European Conference of Human Genetics, Itālija, Milāna , 2014

• Local

• Winter wheat crown and root rota re affected by soil tillage and crop rotation in Latvia Bankina B, Bimšteine G, Ruža A, Priekule I, Paura L, I Vaivade, D Fridmanis , Acta Agriculturae Scandinavica, Section B - Soil & Plant Science, Vol 63, Issue 8, Pages 723-730 , 2013
• Analysis of Polymorphisms at the Adiponectin Gene Locus in Association with Type 2 Diabetes, Body Mass Index and Cardiovascular. I Kalniņa, Latkovskis G, L Ņikitina-Zaķe, Mackevičs V, R Pečulis, I Kāpa, D Fridmanis, Ērglis A, Pīrāgs V, J Kloviņš , Proc. Latvian Acad. Sci. 63: 174-9 , 2009

• Patents

• SET OF OLIGONUCLEOTIDES AND METHOD FOR DETECTION OF FETAL DNA FRACTION IN MATERNAL PLASMA I Radoviča-Spalviņa, V Rovīte, R Pečulis, L Ņikitina-Zaķe, D Fridmanis, J Kloviņš , Europena Patent Office, Application number EP15182851.4 , 2015
• SNP copmosition and method for diagnosing risk for dyslipidemia I Radoviča-Spalviņa, D Fridmanis, L Ņikitina-Zaķe, J Kloviņš , Europena Patent Office EP13192992.9 , 2013
• Viena nukleotīda polimorfismu komplekts paaugstināta vai pazemināta augsta blīvuma lipoproteīna holesterola līmeņa asinīs ģenētiskās predisponētības noteikšanai I Radoviča-Spalviņa, D Fridmanis, L Ņikitina-Zaķe, J Kloviņš , LR patents LV 15022 , 2013
• Rekombinanta himēriska polipeptīda kDNS, kas satur melanokortīna otrā tipa receptora (MC2R) un melanokortīnu receptoru palīgproteīna (MRAP) secības, un tās izmantošana aktīvo vielu testēšanai un terapeitiskiem mērķiem D Fridmanis, J Kloviņš, I Mandrika, R Petrovska, Roga A , LR patents LV 15035 , 2013

• Conference thesis

• The susceptibility variants of type two diabetes in extremely obese individuals V Rovīte, R Petrovska, I Vaivade, I Kalniņa, D Fridmanis, L Zaharenko, R Pečulis, V Pīrāgs, Helgi B. Schioth, J Kloviņš , 29th Congress of the Federation of the International Danube Symposia on Diabetes mellitus and 9th Congress of Central European Diabetes, Jūrmala, Latvija , 2014
• The association of haplotypes in CETP gene with HDL cholesterol levels in Latvian population I Radoviča-Spalviņa, D Fridmanis, I Vaivade, L Ņikitina-Zaķe, J Kloviņš , European School of Genetic Medicine, 2nd course in next generation sequencing, Bertinoro, Italy. Programme and Abstract book, p.34. , 2013
• The association of common SNPs with HDL cholesterol levels in Latvian population I Radoviča-Spalviņa, D Fridmanis, I Vaivade, L Ņikitina-Zaķe, J Kloviņš , European Journal of Human Genetics, Volume 21, Supplement 2, P10.13, p.246. , 2013
• Analysis of the MC4R in relation to obesity in population of Latvia. V Rovīte, R Petrovska, I Kalniņa, I Vaivade, D Fridmanis, L Zaharenko, R Pečulis, Schioth HB, J Kloviņš , European Human Genetics Conference. Nürnberg, Germany. P09-098. , 2012
• Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side-effects in metformin treated type 2 diabetes patients. L Zaharenko, I Kalniņa, Geldnere K, Bumbure A, Ritenberga R, L Ņikitina-Zaķe, D Fridmanis, I Vaivade, V Pīrāgs, J Kloviņš , International Congress on Personalized Medicine: Up Close and Personalized. Florence, Italy. , 2012
• Identification of melanocortin 2 receptor structures responsible for specific membrane expression and ACTH binding specificity D Fridmanis, R Petrovska, Schioth H.B, J Kloviņš , European Congress of Endocrinology 2011. Rotterdam, The Netherlands: European Society of Endocrinology. 26 OC5.3 , 2011

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