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Ilze Radoviča-Spalviņa , Dr. biol.
Researcher
Phone: +371 67808200
E-mail:
ilze@biomed.lu.lv
Publications
International
Association of metformin administration with gut microbiome dysbiosis in healthy volunteers I Elbere, I Kalniņa, I Silamiķelis, Konrade, I, L Zaharenko, L., Sekace, I Radoviča-Spalviņa, D Fridmanis, D Gudrā, V Pīrāgs, J Kloviņš , PLoS ONE, 13 (9), art. no. e0204317. PMID: 30261008 , 2018
A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies D Gudrā, Shoaie, S.,, D Fridmanis, J Kloviņš, Wefer, H., I Silamiķelis, R Pečulis, I Kalniņa, I Elbere, I Radoviča-Spalviņa, Hultcrantz, R., Skenders, G., Leja, M., Engstrand, L , Gut, . Article in Press. PMID: 30242040 , 2018
Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals. I Elbere, I Silamiķelis, M Ustinova, I Kalniņa, L Zaharenko, R Pečulis, Konrade I, Ciuculete DM, Zhukovsky C,, D Gudrā, I Radoviča-Spalviņa, D Fridmanis, Pirags V, Schiöth HB, J Kloviņš , Clinical Epigenetics , 2018
The effects of ibuprofen on activated sludge: Shift in bacterial community structure and resistance to ciprofloxacin Davids, M.,, D Gudrā, I Radoviča-Spalviņa, D Fridmanis, Bartkevics, V., Muter, O. , Journal of Hazardous Materials, 340, pp. 291-299. , 2017
Removal of pharmaceuticals from municipal wastewaters at laboratory scale by treatment with activated sludge and biostimulation Muter, O., Perkons, I., Selga, T., Berzins, A.,, D Gudrā, I Radoviča-Spalviņa, D Fridmanis, Bartkevics, V , Science of the Total Environment, 584-585, pp. 402-413. , 2017
Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients L Zaharenko, I Kalniņa, Geldnere, K., Konrade, I., Grinberga, S., Židzik ,J., Javorský, M., Lejnieks, A., L Ņikitina-Zaķe, D Fridmanis, R Pečulis, I Radoviča-Spalviņa, Hartmane, D., Pugovics, O., Tkáč, I., Klimčáková, L., V Pīrāgs, J Kloviņš , European Journal of Endocrinology , 2016
CAV3 gene sequence variations: National Genome Database and clinics J Stāvusis, I Iņaškina, Ē Jankevics, I Radoviča-Spalviņa, Stavusis, J., Inashkina, I., Jankevics, E., Radovica, I., Micule, I., Strautmanis, J., Naudina, M.S., Utkus, A., Burnyte, B., B Lāce , Acta Neurologica Scandinavica , 2015
Evaluation of massive parallel sequencing as a diagnostic tool for familial hypercholesterolemia I Radoviča-Spalviņa, Berzins R, Latkovskis G, D Fridmanis, L Ņikitina-Zaķe, Ventins K, Ozola G, Erglis A, J Kloviņš , Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, 69 (1-2), pp. 1-7 , 2015
Preparation by alkaline treatment and detailed characterisation of empty hepatitis B virus core particles for vaccine and gene therapy applications A Strods, V Ose-Klinklāva, J Bogans, I Cielēns, G Kalniņš, I Radoviča-Spalviņa, A Kazāks, P Pumpēns, R Renhofa , Scientific Reports, 5, art. no. 11639 , 2015
Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL-C levels in a latvian population I Radoviča-Spalviņa, Latkovskis, G.,, I Silamiķelis, D Fridmanis, I Elbere, Ventins, K., Ozola, G., Erglis, A., J Kloviņš , BMC Medical Genetics, 16 (1), art. no. 86. , 2015
Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population. I Radoviča-Spalviņa, D Fridmanis, I Silamiķelis, L Ņikitina-Zaķe, J Kloviņš , Meta Gene. 2:565-78 , 2014
Massive paralel sequencing in hypercholesterolemic patients of Latvia I Radoviča-Spalviņa, R.Berziņš, D.Silava, I Silamiķelis, D Fridmanis, J Kloviņš , European Conference of Human Genetics, Itālija, Milāna , 2014
The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population. I Radoviča-Spalviņa, D Fridmanis, I Vaivade, L Ņikitina-Zaķe, J Kloviņš , PLoS One. May 13;8(5):e64191. , 2013
Screening of 10 SNPs of LINGO1 gene in patients with essential tremor in the Latvian population. I Radoviča-Spalviņa, I Iņaškina, Smeltere L, Vītols E, Ē Jankevics , Parkinsonism Relat Disord.Jul 6. [Epub ahead of print] , 2011
Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells. K Salmiņa, Ē Jankevics, A Hūna, Perminov D, I Radoviča-Spalviņa, Klymenko T, Ivanov A, Jascenko E, Scherthan H, Cragg M, J Ērenpreisa , Exp Cell Res. 316(13):2099-112 , 2010
Local
Mitochondrial DNA Investigation in Early Onset Neuromuscular Diseases. I Iņaškina, Sergejeva M, I Radoviča-Spalviņa, Ē Jankevics, Vītols E, Pilmane M, Ķikule I, Bērziņa S, Kovaldins A , RSU Zinātniskie raksti 41-44 , 2004
Patents
SET OF OLIGONUCLEOTIDES AND METHOD FOR DETECTION OF FETAL DNA FRACTION IN MATERNAL PLASMA I Radoviča-Spalviņa, V Rovīte, R Pečulis, L Ņikitina-Zaķe, D Fridmanis, J Kloviņš , Europena Patent Office, Application number EP15182851.4 , 2015
SNP copmosition and method for diagnosing risk for dyslipidemia I Radoviča-Spalviņa, D Fridmanis, L Ņikitina-Zaķe, J Kloviņš , Europena Patent Office EP13192992.9 , 2013
Viena nukleotīda polimorfismu komplekts paaugstināta vai pazemināta augsta blīvuma lipoproteīna holesterola līmeņa asinīs ģenētiskās predisponētības noteikšanai I Radoviča-Spalviņa, D Fridmanis, L Ņikitina-Zaķe, J Kloviņš , LR patents LV 15022 , 2013
Conference thesis
Pharmacokinetics and pharmacogenetics of metformin in 21 healthy participant after 500 mg single-dose administration L Zaharenko, I.Konrāde, A.Lejnieks, V Pīrāgs, D.Hartmane, S.Grinberga, O.Pugovičs, I Radoviča-Spalviņa, R Pečulis, J Kloviņš , 29th Congress of Central European Diabetes Association. Organizator: Central European Diabetes Association Federation of International Danube Symposia on Diabetes mellitus, Jūrmala, Latvija , 2014
The association of haplotypes in CETP gene with HDL cholesterol levels in Latvian population I Radoviča-Spalviņa, D Fridmanis, I Vaivade, L Ņikitina-Zaķe, J Kloviņš , European School of Genetic Medicine, 2nd course in next generation sequencing, Bertinoro, Italy. Programme and Abstract book, p.34. , 2013
The association of common SNPs with HDL cholesterol levels in Latvian population I Radoviča-Spalviņa, D Fridmanis, I Vaivade, L Ņikitina-Zaķe, J Kloviņš , European Journal of Human Genetics, Volume 21, Supplement 2, P10.13, p.246. , 2013
Study of gene Caveolin3 in Latvian population. J Stāvusis, B Lāce, I Iņaškina, Ē Jankevics, I Radoviča-Spalviņa , European J Hum Gen, 20 Suppl. 1: p391-392. , 2012
Screening of LINGO1 gene in patients with essential tremor in Latvian population. I Radoviča-Spalviņa, I Iņaškina, Smeltere L, Vitols E, Ē Jankevics , The 7th Baltic Congress Of Neurology Programme and Abstract book, p.136. , 2012
A self-renewal strategy of tumour cells through reversible polyploidy after genotoxic treatment K Salmiņa, Ē Jankevics, A Hūna, Perminov D, I Radoviča-Spalviņa, Ivanova A, Cragg M, J Ērenpreisa , Transcription and Disease Symposium, London, UK , 2011
Screening of 10 SNPs of LINGO1 gene in patients with essential tremor in the Latvian population. I Radoviča-Spalviņa, I Iņaškina, Smeltere L., Vitols E., Ē Jankevics , European Human Genetics Conference. May 28 - 31, Amsterdam, The Netherlands. Abstracts. European Journal of Human Genetics Vol. 19:263. , 2011
The 2nd OpenGENE Young Investigator Workshop in Baltic Region. “Resequencing, genotyping and statistical analysis of common complex diseases”. I Radoviča-Spalviņa , The 2nd OpenGENE Young Investigator Workshop in Baltic Region. “Resequencing, genotyping and statistical analysis of common complex diseases”. August 23-26, Tartu, Estonia. P.26. , 2011
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