About us

Groups

• J. Klovins lab

Projects

• Genetic investigation of urban Northern goshawks (Accipiter gentilis) in Riga - launching into wild population genomics
• Investigation of interaction of smoked dietary products with gut microbiome

Publications

• International

• Association of metformin administration with gut microbiome dysbiosis in healthy volunteers I Elbere, I Kalniņa, I Silamiķelis, Konrade, I, L Zaharenko, L., Sekace, I Radoviča-Spalviņa, D Fridmanis, D Gudrā, V Pīrāgs, J Kloviņš , PLoS ONE, 13 (9), art. no. e0204317. PMID: 30261008 , 2018
• A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies D Gudrā, Shoaie, S.,, D Fridmanis, J Kloviņš, Wefer, H., I Silamiķelis, R Pečulis, I Kalniņa, I Elbere, I Radoviča-Spalviņa, Hultcrantz, R., Skenders, G., Leja, M., Engstrand, L , Gut, . Article in Press. PMID: 30242040 , 2018
• Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals. I Elbere, I Silamiķelis, M Ustinova, I Kalniņa, L Zaharenko, R Pečulis, Konrade I, Ciuculete DM, Zhukovsky C,, D Gudrā, I Radoviča-Spalviņa, D Fridmanis, Pirags V, Schiöth HB, J Kloviņš , Clinical Epigenetics , 2018
• Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients L Zaharenko, I Kalniņa, Geldnere, K., Konrade, I., Grinberga, S., Židzik ,J., Javorský, M., Lejnieks, A., L Ņikitina-Zaķe, D Fridmanis, R Pečulis, I Radoviča-Spalviņa, Hartmane, D., Pugovics, O., Tkáč, I., Klimčáková, L., V Pīrāgs, J Kloviņš , European Journal of Endocrinology , 2016
• The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity V Rovīte, R Petrovska, I Vaivade, I Kalniņa, D Fridmanis, L Zaharenko, R Pečulis, V Pīrāgs, Schioth HB, J Kloviņš , Mol Biol Rep. 41(3):1491-500 , 2014
• Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity. Almén MS, Nilsson EK, Jacobsson JA, I Kalniņa, J Kloviņš, Fredriksson R, Schiöth HB , Gene. 548(1):61-7 , 2014
• Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes. I Kalniņa, L Zaharenko, I Vaivade, V Rovīte, L Ņikitina-Zaķe, R Pečulis, D Fridmanis, Geldnere K, Jacobsson JA, Almen MS, V Pīrāgs, Schiöth HB, J Kloviņš , Gene. Sep 25;527(2):462-8. , 2013
• Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population Kalnina I, Geldnere K, Tarasova L, Nikitina-Zake L, Peculis R, Fridmanis D, Pirags V, Klovins J , Exp Clin Endocrinol Diabetes 2012 Mar 22. [Epub ahead of print] , 2012
• Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children Sällman Almén M, Rask-Andersen M, Jacobsson JA, Ameur A, Kalnina I, Moschonis G, Juhlin S, Bringeland N, Hedberg LA, Ignatovica V, Chrousos GP, Manios Y, Klovins J, Marcus C, Gyllensten U, Fredriksson R, Schiöth HB , Int J Obes (Lond) 2012 Apr 24. [Epub ahead of print] , 2012
• Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients Tarasova L, Kalnina I, Geldnere K, Bumbure A, Ritenberga R, Nikitina-Zake L, Fridmanis D, Vaivade I, Pirags V, Klovins J , Pharmacogenet Genomics Jun 25. [Epub ahead of print] , 2012
• Identification of domains responsible for specific membrane transport and ligand specificity of the ACTH receptor (MC2R) D Fridmanis, R Petrovska, I Kalniņa, Slaidina M, R Pečulis, Schiöth HB, J Kloviņš , Mol Cell Endocrinol. 321(2):175-83 , 2010
• Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI. I Kalniņa, I Kāpa, Pirags V, V Rovīte, Schiöth HB, J Kloviņš , BMC Med Genet. 10:63 , 2009
• The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells. Lagerstrom MC, Rabe N, Haitina T, I Kalniņa, Hellstrom AR,, J Kloviņš, Kullander K, Schioth HB , J Neurochem. 100(4):1129-42. , 2007

• Local

• Analysis of Polymorphisms at the Adiponectin Gene Locus in Association with Type 2 Diabetes, Body Mass Index and Cardiovascular. I Kalniņa, Latkovskis G, L Ņikitina-Zaķe, Mackevičs V, R Pečulis, I Kāpa, D Fridmanis, Ērglis A, Pīrāgs V, J Kloviņš , Proc. Latvian Acad. Sci. 63: 174-9 , 2009

• Conference thesis

• The susceptibility variants of type two diabetes in extremely obese individuals V Rovīte, R Petrovska, I Vaivade, I Kalniņa, D Fridmanis, L Zaharenko, R Pečulis, V Pīrāgs, Helgi B. Schioth, J Kloviņš , 29th Congress of the Federation of the International Danube Symposia on Diabetes mellitus and 9th Congress of Central European Diabetes, Jūrmala, Latvija , 2014
• Association of polymorphisms representing obesity-related loci comprising FTO and TMEM18 with type 2 diabetes and age at diagnosis of the disease in the population of Latvia. I Kalniņa, L Zaharenko, I Vaivade, V Rovīte, Jacobsson JA, Almen MS, Schiöth HB, V Pīrāgs, J Kloviņš , European Human Genetics Conference. Nürnberg, Germany. P09-136. , 2012
• Analysis of the MC4R in relation to obesity in population of Latvia. V Rovīte, R Petrovska, I Kalniņa, I Vaivade, D Fridmanis, L Zaharenko, R Pečulis, Schioth HB, J Kloviņš , European Human Genetics Conference. Nürnberg, Germany. P09-098. , 2012
• Common Variants in FTO and TMEM18 Loci Associate with Type 2 Diabetes and BMI in the Population of Latvia. I Kalniņa, L Zaharenko, I Vaivade, V Pīrāgs, Jacobsson JA, Almen MS, Schiöth HB, J Kloviņš , International Congress on Personalized Medicine: Up Close and Personalized. Florence, Italy. P-10. , 2012
• Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side-effects in metformin treated type 2 diabetes patients. L Zaharenko, I Kalniņa, Geldnere K, Bumbure A, Ritenberga R, L Ņikitina-Zaķe, D Fridmanis, I Vaivade, V Pīrāgs, J Kloviņš , International Congress on Personalized Medicine: Up Close and Personalized. Florence, Italy. , 2012
• Association of NPBWR1 and NPBWR2 gene polymorphisms with hypertension I Kalniņa, Latkovskis G.,, V Pīrāgs, J Kloviņš , European Human Genetics Conference. 2011. Amsterdam RAI, The Netherlands , 2011
• Identification of polymorphisms in NPBWR2 gene associated with hypertension. J Kloviņš, R Petrovska, Latkovskis G., V Pīrāgs, Schioth H.B, I Kalniņa , The 12th International Congress of Human Genetics/61st Annual Meeting of The American Society of Human Genetics. 2011. Montreal, Canada , 2011
• Association of genetic polymorphisms in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein with the metformin intolerance and weight lowering in patients of type 2 diabetes. L Zaharenko, J Kloviņš, I Kalniņa, Bumbure A, Reitenberga R., Geldnere K., L Ņikitina-Zaķe, V Pīrāgs , European Congress of Endocrinology 2011. 2011. Rotterdam, The Netherlands. 26 OC4.3. , 2011

Quick links

• Purchases
• Purchases archive
• Core Facilities
• Facilities and services
• EURAXESS