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Ivars Petrovskis , Dr. biol
Senior researcher
Phone: +371 67808213
E-mail:
ivars@biomed.lu.lv
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A. Dishlers lab
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International
Crystal structure of the membrane attack complex assembly inhibitor BGA71 from the Lyme disease agent Borrelia bavariensis K Brangulis, I Akopjana, I Petrovskis, A Kazāks, Kraiczy, P.,, K Tārs , Scientific Reports, 8 (1), art. no. 11286. PMID: 30050126 , 2018
Crystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H K Brangulis, I Petrovskis, A Kazāks, I Akopjana, K Tārs , Biochimica et Biophysica Acta - Proteins and Proteomics, 1854 (5), pp. 349-355 , 2015
Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily K Brangulis, Jaudzems, K., I Petrovskis, I Akopjana, A Kazāks, K Tārs , Journal of Structural Biology, 192 (3), pp. 320-330. , 2015
Comparative Immunogenicity in Rabbits of the Polypeptides Encoded by the 5′ Terminus of Hepatitis C Virus RNA I Sominska, J Jansons, A Dovbenko, Petrakova, N., I Liekniņa, M Mihailova, Latyshev, O., Eliseeva, O., I Stahovska, I Akopjana, I Petrovskis, Isaguliants, M. , Journal of Immunology Research, art. no. 762426 , 2015
The Hepatitis B Virus Core Variants that Expose Foreign C-Terminal Insertions on the Outer Surface of Virus-Like Particles A Dišlers, D Skrastiņa, R Renhofa, I Petrovskis, V Ose-Klinklāva, I Liekniņa, J Jansons, P Pumpēns, I Sominska , Molecular Biotechnology, 57 (11-12), pp. 1038-1049 , 2015
Structural characterization of CspZ, a complement regulator factor H and FHL-1 binding protein from Borrelia burgdorferi. K Brangulis, I Petrovskis, A Kazāks, J Bogans, Otikovs M, Jaudzems K, R Ranka, K Tārs , FEBS J., 281(11):2613-22 , 2014
Silica Nanoparticles as the Adjuvant for the Immunisation of Mice Using Hepatitis B Core Virus-Like Particles. D Skrastiņa, I Petrovskis, I Liekniņa, J Bogans, R Renhofa , PLoS ONE 9(12): e114006 , 2014
Characterisation of antigenic properties of recombinant B. burgdorferi outer surface proteins from Pfam54 family G.Muzje, I Petrovskis, K Vilks, V Čapligina, D.Bandere, R Ranka , 2nd Congress of Baltic microbiologists, Tartu, Igaunija , 2014
Crystal structure of the infectious phenotype-associated outer surface protein BBA66 from the Lyme disease agent Borrelia burgdorferi. K Brangulis, I Petrovskis, A Kazāks, K Tārs, R Ranka , Ticks Tick Borne Dis. Feb;5(1):63-8. , 2014
Fibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragments. R Ranka, I Petrovskis, I Sominska, J Bogans, R Brūvere, I Akopjana, V Ose-Klinklāva, I Timofējeva, K Brangulis, P Pumpēns, V Baumanis , Nanomedicine. Jan;9(1):65-73. , 2013
Plasmid Dimerization Increases the Production of Hepatitis B Core Particles in E. coli. I Bērza, A Dišlers, I Petrovskis, K Tārs, A Kazāks , Biotechnology and Bioprocess Engineering, Sep Vol 18, Issue 5, pp 850-857 , 2013
A VLP library of C-terminally truncated Hepatitis B core proteins: correlation of RNA encapsidation with a Th1/Th2 switch in the immune responses of mice. I Sominska, D Skrastiņa, I Petrovskis, A Dišlers, I Bērza, M Mihailova, J Jansons, I Akopjana, I Stahovska, D Dreiliņa, V Ose-Klinklāva, P Pumpēns , PLoS One. Sep 23;8(9):e75938. , 2013
Chimeric derivatives of hepatitis B virus core particles carrying major epitopes of the rubella virus e1 glycoprotein. D Skrastiņa, I Petrovskis, Petraityte R, I Sominska, V Ose-Klinklāva, I Liekniņa, J Bogans, Sasnauskas K, P Pumpēns , Clin Vaccine Immunol. Nov;20(11):1719-28. , 2013
Structure of an outer surface lipoprotein BBA64 from the Lyme disease agent Borrelia burgdorferi which is critical to ensure infection after a tick bite. K Brangulis, K Tārs, I Petrovskis, A Kazāks, R Ranka, V Baumanis , Acta Crystallogr D Biol Crystallogr. Jun;69(Pt 6):1099-107. , 2013
Structural characterization of the Borrelia burgdorferi outer surface protein BBA73 implicates dimerization as a functional mechanism. K Brangulis, I Petrovskis, A Kazāks, V Baumanis, K Tārs , Biochem Biophys Res Commun. May 17;434(4):848-53. , 2013
Local
Analysis of the seroreactivity to recombinant B. burgdorferi antigens BBA65 and BBA73. R Ranka, Muzje G, K Brangulis, I Petrovskis, K Vilks, V Čapligina , RSU Collection of Scientific Papers 2014, Research articles in medicine & pharmacy, 40-46 p , 2014
Display vectors. I. Hepatitis B core particle as a display moiety. Borisova G, Borschukova O, D Skrastiņa, Mezule G, A Dišlers, I Petrovskis, V Ose-Klinklāva, Gusars I, P Pumpēns, E Grēns , Proc. Latvian Acad. Sci. 51:1-7 , 1997
Patents
Paņēmiens tukšu un ar nukleīnskābēm pildītu hepatīta B vīrusa core-proteīna kapsīdu iegūšanai I Liekniņa, I Petrovskis, I Sominska, J Bogans, I Akopjana, P Pumpēns, A Dišlers , LR patenta pieteikuma nr. P-14-81 , 2015
COUPLING OF BORRELIAL PROTEIN BB0689 TO VIRUS-LIKE PARTICLES FOR GENERATION OF LYME DISEASE VACCINE K Tārs, I Petrovskis, A Dišlers, D Skrastiņa, A Zeltiņš, K Brangulis, S Koteloviča , Europena Patent Office, Application number EP15182845.6 , 2015
Anti-HCV individuālas terapeitiskas vakcīnas prototips I Sominska, J Jansons, P Pumpēns, I Petrovskis, D Skrastiņa, G. Sudmale , LR patents LV 14987 , 2013
Ekspresijas sistēma HBc-preS1 vīrusveidīgo daļiņu iegūšanai A Dišlers, I Petrovskis, I Liekniņa, I Bērza, J Bogans, I Akopjana, I Sominska, P Pumpēns , LR patents LV 14945 , 2013
Prokariotiska un eikariotiska ekspresijas vektoru komplekts himēra HBV nukleokapsīda ekspresijai un kombinētas anti-HBV un anti-HCV imunoatbildes iegūšanai. I Sominska, M Mihailova, J Jansons, D Skrastiņa, J Aleksejeva, I Petrovskis, P Pumpēns , LR patents Nr. 14161 , 2010
Ekspresijas sistēma rekombinanto vīrusveidīgo daļiņu iegūšanai A Dišlers, I Sominska, A Kazāks, I Petrovskis, Zariņa I , LR patents Nr. 13587 , 2008
Conference thesis
Crystal structure of the B. Burgdorferi outer surface protein of the paralogous gene family PFam5 R Ranka, K Brangulis, K Tārs, I Petrovskis, V Baumanis , Gordon Research Conferences frontiers of science, Venturi, ASV , 2014
Successful creation of chimeric virus-like particles maintaining fibronectin-binding property from B.burgdorferi BBK32 protein R Ranka, I Petrovskis, I Sominska, K Brangulis, P Pumpēns, V Baumanis , XII International Jena Symposium on Tick-borne Diseases. Weimar, Vācija , 2013
Study of B. burgdorferi outer membrane proteins by protein-protein interaction approach R Ranka, K Vilks, K Brangulis, I Petrovskis, V Čapligina, V Baumanis , 38th FEBS Congress, St.Petersburg, Krievija. , 2013
Crystal structure of an outer surface protein BBA64 from Borrelai burgdorferi in comparison to BbCRASP-1. K Brangulis, K Tārs, I Petrovskis, R Ranka, V Baumanis , The FEBS Journal, v.279, S.1, p.467 , 2012
Individualized Anti-HCV/HBV Vaccine Prototype. I Sominska, D Skrastiņa, I Petrovskis, V Ose-Klinklāva, I Akopjana, I Stahovska, P Pumpēns , IX Annual Conference of the New Visby Network on Hepatitis C. Saint Petersburg, Russia. , 2012
Presentation of individual Hepatitis C Hipervariable region. G Varblane, I Sominska, I Petrovskis, V Ose-Klinklāva, Sondore V, Arša F, P Pumpēns , IX Annual Conference of the New Visby Network on Hepatitis C. Saint Petersburg, Russia. , 2012
Packaging of Nonmethylated CG motifs into Virus-Like Particles Bearing Hepatitis C Virus (HCV) Nonstructural Protein 3 Sequences for Induction of Vigorous HCV Specific Cytotoxic T Cell Response M Mihailova, A Dovbenko, J Bogans, I Petrovskis, V Ose-Klinklāva, I Sominska, P Pumpēns , 4th Annual Proteins Congress & Vaccines Congress, London, UK , 2011
B.burgdorferi virsmas proteīna BbA69 klonēšana, ekspresija, attīrīšana un kristalizācija. K Brangulis, R Ranka, I Petrovskis, K Tārs, Medne R., Bandere D., V Baumanis , RSU Zinātniskā Konference, Rīgā, , 2011
Prevalence of tick born pathogens in ticks collected from birds in Latvia. K Brangulis, R Ranka, I Petrovskis, K Tārs, V Čapligina, V Baumanis , IX International Jena symposium on tick-borne diseases Abstracts, Jena , 2011
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