Research Directions and labs
Research
Cancer research

A. Linē lab

Aija Linē , Dr. biol.

Scientific director / Senior researcher
Phone: +371808208
E-mail: aija@biomed.lu.lv

Research

The main focus of our group is the discovery and validation of blood-based biomarkers for the early detection and prognosis of cancer, disease monitoring and detecting the presence of drug targets. First, we are working on identifying tumour antigens eliciting autoantibody production in cancer patients and studying their relevance for the diagnosis and prognosis of various cancers. Secondly, we recently engaged in studies aiming to evaluate to what degree the cancer-derived extracellular vesicles (EVs) represent the genetic make-up and intratumoural heterogeneity of cancer and how they contribute to the cancer-immune cell cross-talk. Furthermore, we are interested in the impact of extracellular acidity on the functional phenotype of tumour infiltrating immune cells and in inducing the formation of tertiary lymphoid structures (TLS) in the tumour microenvironment as a putative therapeutic strategy. 

 

Cooperation partners:

  

  

  

 

 

 

 

  

 

Scientific Staff

Pavels Zajakins , Dr. biol., pz@magisters.net

Pavels Zajakins , Dr. biol.

Researcher
Phone: +371 67808200
E-mail: pz@magisters.net

Artūrs Ābols , Dr. biol., arturs@biomed.lu.lv

Artūrs Ābols , Dr. biol.

Researcher
Phone: +371 67808208
E-mail: arturs@biomed.lu.lv

Moto: How we spend our days is, of course, how we spend our lives. /Annie Dillard/

Andreas Berger , MSc. biol., andreas.berger@biomed.lu.lv

Andreas Berger , MSc. biol.

Research assistants
Phone: +371 67808208
E-mail: andreas.berger@biomed.lu.lv

Edgars Endzeliņš , MSc. biol., edgars.endzelins@gmail.com

Edgars Endzeliņš , MSc. biol.

Research assistants
Phone: +371 67808208
E-mail: edgars.endzelins@gmail.com

Irēna Meistere , MSc. biol., irena_m@biomed.lu.lv

Irēna Meistere , MSc. biol.

Research assistants
Phone: +371 67808208
E-mail: irena_m@biomed.lu.lv

Moto: I'm a great believer in luck and I find the harder I work, the more I have of it. /Thomas Jefferson/

Elīna Zandberga , MSc. biol., elina@biomed.lu.lv

Elīna Zandberga , MSc. biol.

Research assistants
Phone: +371 26529330
E-mail: elina@biomed.lu.lv

Cristina Bajo Santos , MSc. biol., crisbs88@hotmail.com

Cristina Bajo Santos , MSc. biol.

Research assistants
Phone: +371 67808208
E-mail: crisbs88@hotmail.com

Rasita Tolekiene , MSc. biol., raskkita@gmail.com

Rasita Tolekiene , MSc. biol.

Research assistants
Phone: +371 67808208
E-mail: raskkita@gmail.com

Lilite Sadovska , MSc. biol., lilite@biomed.lu.lv

Lilite Sadovska , MSc. biol.

Research assistants
Phone: +371 28222543
E-mail: lilite@biomed.lu.lv

Kristīne Soboļevska , BSc. biol., k.sobolevska@gmail.com

Kristīne Soboļevska , BSc. biol.

Laboratory assistant
Phone: +371 67808200
E-mail: k.sobolevska@gmail.com

Publications


All publications

Quick links

Group quick links

Current Projects


All group projects

Latest activities

A review on Diagnostic, prognostic and predictive value of cell-free miRNAs in prostate cancer is published in Molecular Cancer (IF=5.888).
The results obtained within The National Research Program BIOMEDICINE on the role of CAIX in the induction of immunosuppressive microenvironment in breast cancer were presented at 2nd Symposium on Advances in Cancer Immunology and Immunotherapy in Athens and obtained the 2nd award in the poster competition


Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".