The main research area of our group is investigation of the molecular bases of different biological functions of medically-important pathogens with especial focus on pathogen-host interaction. First, we are interesting to expand our understanding of the pathogenesis of tuberculosis (TB), mechanisms of spread, and mechanisms underlying drug resistance of Mycobacterium tuberculosis. Recently, we engaged in paleopathology studies aiming to understand the mechanisms by which Mycobacterium tuberculosis and the human host have co-evolved. Second, we are working on deciphering factors involved in determining the spread of the important tick-borne infections in Europe, and our studies are related to genetic, epidemiological and biological aspects of various tick-borne diseases. Third, we are interesting in deciphering of various factors leading to the reactivation of latent infections in aged population such as the immunosenescence processes, and genetic predisposition to infectious diseases (clinical tuberculosis).