Development of targeted alphaviral RNA delivery using modified magnetic nanoparticles
Project Title: "Development of targeted alphaviral RNA delivery using modified magnetic nanoparticles "
Funding: Latvia-Belarus collaborative project
Principle Investigator: Dr.biol. A. Zajakina
Biomedical Research and Study Centre (LV)
Institute of Physical Organic Chemistry NAS (BY)
The goal of the project is to develop a system for efficient and specific delivery of self-replicating viral RNA into the tumour. For this purpose we plan to apply hybrid magnetic nanoparticles coated with alphaviral RNA possessing oncolytic properties. The particles will be modified with tumour homing peptides and will carry the fluorescent dyes for efficient examination of particles biodistribution in tumour models.