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Engineering of extracellular vesicles to transfer tumor suppressor miRNA to cancer cells




Funding: European Regional Development Fund (ERDF) “On Implementation of Activity “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”

Project Title:Engineering of extracellular vesicles to transfer tumor suppressor miRNA to cancer cells

Project Nr.:

Period: 36 month (1st September 2017 – 31 st August 2020)

Project costs: 133 806,00 EUR

Project implementer: Dr.biol. A. Ābols

The aim of this study is to engineer donor cells to produce EVs that contain therapeutically relevant miRNAs and target ER+ breast and thyroid cancer cells thus providing a proof-of-principle that engineered EVs can be exploited for targeted drug delivery in cancer.

This project is expected to deliver novel engineered EVs with a surface marker allowing to conjugate them with different cancer specific antibodies and enclosed tumour suppressor miRNAs in order to treat different cancer types. These EVs will serve as the basis for the development of new therapies for different types of cancer.

Information published: 01.09.2017.


Progress of the project

1 September 2017 - 30 November 2017

The latest literature was studied and detailed plan of the project execution was developed during these months. The plan was presented to the scientific consultant. Also, the topic of the project was explained to the general public in non - scientific language during "Zinātnieku nakts" event. The modification of the stem cells was started by selecting the best gene candidates and modification protocols from literature and schematic overview of the modified genes were developed.

Information published: 30.11.2017.


Progress of the project

1 December 2017 - 28 February 2018

During this period there was created cell cultures stocks used in this project and tested for mycoplasma. In order to create hybrid proteins primers were designed and some fragments were already amplified, trimmed and purified for further manipulations. Also, there was prepared and presented lecture about project aims and topics in scientific forum "Ko nozīmē būt zinātniekam" and organised several excursions and demonstrations for students interested in this field during these months. Preparation for the next years "Zinātnieku nakts" event was started.

Information published: 28.02.2018.

Mājas lapas izstrādi finansēja ERAF aktivitātes projekts Nr. 2010/0196/2DP/ "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".