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Stimulated changes of conformations of Her-receptors in breast cancer cells and their consequences in genome organisation



Aims of the project:

  • To investigate early Her-receptor cascade activation and genome (chromatin) response against it, using  super-resolution microscope and structure characterisation with molecular biology methods.
  • To acquire new competencies in molecular biology and microscopy methods.
  • To establish new efficient and sustainable collaboration network between Latvia and Germany for chromatin biophysics research.


Target group:

  • Scientists and students of Latvian Biomedical Research and Study Centre, Laboratory of Cancer Cell Biology.
  • Scientists and students of Heidelberg University, Kirchhoff-Institute for Physics, Prof. Hausmann group.


Main activities of the project:

  • Molecular biology experiments for characterization of functional chromatin changes, its structure analysis and software-based analysis of microscopic images in Riga.
  • Chromatin structure analysis with supperresolution microscope and software-based analysis of microscopic images in Heidelberg.
  • ‘Know-how‘ exchange, hands-on training and knowledge transfer.
  • Analysis of results, preparation and submission of scientific publication.


Planned public events:

  • Seminar „Chromatin organisation mechanisms“ Heidelberg (2015. April).
  • Seminar „ Nano- and mesoscopic level structures in cell systems”  Riga (2015. October). Speakers include: Prof. Hausmann (Heidelberg) un Prof. A. Giuliani (Rome).

Mājas lapas izstrādi finansēja ERAF aktivitātes projekts Nr. 2010/0196/2DP/ "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".