31.05.2016 at 08:48:29    

 Welcome, Guest. Please Login.

This is the old and discontinued version of the webpage.
Please visit the current version HERE.

 Sticky News
Discuss in forum
 
Date: 15.03.2010 at 15:49:14
This topic contains 2 attachments
New post under construction: Latvian BMC video files are available. PUBLIC RELATIONS 2006-2008  
 
Please click on the link below: BMC-videos
Discuss in forum
Date: 17.03.2008 at 12:23:47
 News
BMC 2008/2009: Patenti un pieteikumi [Patents and applications]
 
1. Tsimanis AY, Saripo A, Leonciks A , Kurbatska V, Rudevica Z. Human recombinant soluble CCR5 chemokine receptor. US Patent and and Trademark Office. Application No 61/065, Date 02/11/2008.
 
2. Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity. Renner, W,  Bachmann, MF.,  Cielens, I,  Coester, CJ,  Dietmeier, K,  Fuchs S, Manolova, V, Maurer P, Pumpens; P,  Renhofa, R, Tissot Alain, Zou; Yu.   European Patent Application EP1973608. Publication date: 10/01/2008; National Phase in South Africa of PCT/EP2006/06734. Date July 11, 2008.
 
3. Virus-Like Particles Comprising a Fusion Protein of the Coat Protein of Ap205 and an Antigenic Polypeptide. Bachmann, Martin F,  Tissot, Alain,  Jennings, Gary,  Renhofa, Regina,  Pumpens, Paul,  Cielens, Indulis. US20080292652 Patent application. Publication date: 11/27/2008.
 
4. Packaging of immunostimulatory substances into virus-like particles: method of preparation and use. Bachmann, MF., Storni, T,  Maurer, P, Tissot, A, Schwarz, K, Meijerink, E, Lipowsky, G, Pumpens, P, Cielens, I, Renhofa, R. EP1450856 Patent. Publication date: 11/11/2009; Japanese Patent JP2009197001. Publication date: 09/03/2009; Patentanmeldung in Indien Nr. 3160/CHENP/2009.  
 
5. Leonciks A., Kurbatska V., Rudevica Z., Human rekombinant soluble CCR5 chemokine receptor, Confirmation number 5273, Application number 61/061, 151(US61/065, 151) United States Patent and Trademark Office 11/02/2008 (Foreign filing licence granted:03/03/2008).
 
6. Ekspresijas sistēma rekombinanto vīrusveidīgo daļiņu iegūšanai. Dišlers A, Sominska I, Kazaks A, Petrovskis I, Zarina I. Latvijas Republikas patents LV 13587. Publikācijas datums 20.02.2008.  
 
7. Rekombinants rauga Pichia pastoris celms cilvēka hepatīta B vīrusa (subtips ayw) nukleokapsīdu iegūšanai. Kazāks A., Freivalds J., Pumpēns P., Dišlers A. Latvijas Republikas patents LV 13740 Publikācijas datums 02.10.2008
 
8. Molecular antigen arrays. Bachmann, MF.,  Tissot, A,  Pumpens, P,  Cielens, I,  Renhofa, R. US7494656 Patent. Publication date: 02/24/2009.  
 
9. Pilna garuma HBV core proteīna kapsīdu attīrīšana, rekonstrukcija un pakošana. Renhofa R, Ozols J, Ose V, Pumpēns P. Latvijas Republikas patents LV 13958, publikācijas datums 12/2009.  
 
10. Antibiotikas doksurubicīna iepakošana bakteriofāga apvalka proteīna veidotajās nanodaļiņās- kapsīdās. Renhofa R., Ozols J., Cielēns I., Strods A. Latvijas Republikas patents LR 13979, publikācijas datums 20.11.2009.
 
11. Sominska I., Mihailova M.,Jansons J., Skrastina D., Aleksejeva J., Petrovskis I., Pumpens P. Prokariotiska un eikariotiska ekspresijas vektoru komplekts himera hepatīta B virusa nukleokapsida ekspresijas un kombinētas anti-HBV imunatbildes iegūšanai. Patenta
pieteikums P-08-164 no 17.09.08.
 
12. Magnētisko nanodaļiņu iepakošana HBV core proteīna veidotajās kapsīdās. Renhofa R., Dišlers A., Ozols J., Ose-Klinklāva., Punpēns P. Latvijas patenta pieteikums P-09-156, 2009.  
Discuss in forum
 
Date: 23.03.2010 at 13:38:38
This topic contains 1 attachment
Valdis Bērziņš Readings 2008
 
Presentation by Viesturs Baumanis: Valdis Bērziņš 65
please follow the link below
Discuss in forum
Date: 25.03.2008 at 12:30:11
Mājas lapā atvērta sadaļa iepirkumi
Discuss in forum
 
Date: 29.05.2006 at 13:37:38
  2009
BMC publikācijas, 2009. gads
Publikācijas starptautiskos zinātniskos žurnālos:
1.         Zhang W, Caspell R, Karulin AY, Ahmad M, Haicheur N, Abdelsalam A, Johannesen K, Vignard V, Dudzik P, Georgakopoulou K, Mihaylova A, Silina K, Aptsiauri N, Adams V, Lehmann PV, McArdle S. ELISPOT assays provide reproducible results among different laboratories for T cell immune monitoring – even in hands of ELISPOT-inexperienced investigators. J Immunotoxicol, 2009 Dec; 6(4):227-34.
2.      Jumutcs V, Zayakin P, Linē A. Antigen Reduction Applied to Support Vector Machine Classification for Melanoma-Related Diagnostics. Polish J. of Environ. Stud, 2009, 18 (4A):3-7.
3.      Kalnina Z, Silina K, Bruvere R, Gabruseva N, Stengrevics A, Barnikol-Watanabe S, Leja M, Line A. Molecular characterisation and expression analysis of SEREX-defined antigen NUCB2 in gastric epithelium, gastritis and gastric cancer. Eur J Hisopathol, 2009, Jan-Mar; 53 (1):7-18.
4.      Pumpens P., Ulrich R., Sasnauskas K., Kazaks A., Ose V., Grens E. Construction of novel vaccines on the basis of the virus-like particles: Hepatitis B virus proteins as vaccine carriers, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 205-248.
5.      Rabe B, Delaleau M, Bischof A, Foss M, Sominskaya I, Pumpens P, Cazenave C, Castroviejo M, Kann M Nuclear entry of hepatitis B virus capsids involves disintegration to protein dimers followed by nuclear reassociation to capsids. PLoS Pathog. 2009 Aug;5(8):e1000563. Epub 2009 Aug 28.
6.      Alekseeva E, Sominskaya I, Skrastina D, Egorova I, Starodubova E, Kushners E, Mihailova M, Petrakova N, Bruvere R, Kozlovskaya T, Isaguliants M, Pumpens P. Enhancement of the expression of HCV core gene does not enhance core-specific immune response in DNA immunization: advantages of the heterologous DNA prime, protein boost immunization regiment. Genet Vaccines Ther. 2009 Jun 8;7(1):7.  
7.      Sendi H., Mehrab-Mohseni M., Shahraz S., Norder H., , Noorinayer B., Zali M.R., Pumpens P.,  Magnius L.O. CTL escape mutation of core protein are more frequent in strains of HBeAg negative patients with low viral load. 2009. J. Clin. Virol., Sep 1. Nov;46(3):259-264. Epub 2009 Sep 12  
8.      Bessa J, Jegerlehner A, Hinton HJ, Pumpens P, Saudan P, Schneider P, Bachmann MF Alveolar Macrophages and Lung Dendritic Cells Sense RNA and Drive Mucosal IgA Responses. J Immunol. 2009 Sep 15;183(6):3788-99. Epub 2009 Aug 26.
9.      Sominskaya I, Mihailova M, Jansons J, Legzdina D, Pumpens P, Arsha F, Keish J, Sondore V, Rozentale B, Viksna L. Epidemiological study of Hepatitis B virus genotypes in Latvia. 2009. Submitted to The Open Hepatology Journal.
10.      Bremer CM, Sominskaya I, Skrastina D, Pumpens P, Abd El Wahed A, Beutling U, Frank R, Fritz HI, Hunsmann G, Gerlich WH, Glebe D. Neutralizing epitopes in the preS1 attachment site of hepatitis B virus are partially masked by N-terminal myristoylation. 2009, submitted to the PLoS ONE.  
11.      De-Almeida D.E., Ling S., Pi M., Hartmann-Scruggs A.M., Pumpens P., Holoshitz J. Immune dysregulation by the rheumatoid arthritis shared epitope. 2009, submitted to J. Immunol.  
12.      Ling S., Cheng A., Pumpens P., Michalak M., Holoshitz J. Mapping of the Rheumatoid Arthritis Shared Epitope Binding Site on Calreticulin. 2009, submitted to the PNAS.
13.      Ulrich R.G., Gedvilaite A., Voronkova T., Kazaks A., Sasnauskas K., Johne R. Polyoma-virus derived virus-like particles, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 249-275.
14.      Kazaks A., Voronkova T. Papilloma-virus derived virus-like particles, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 277-297.
15.      Zeltins A. Plant virus biotechnology platforms for expression of medicinal proteins, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 481-517.
16.      Zajakina A., Niedre-Otomere B., Alekseeva E., Kozlovska T.  Alphaviruses: multiplicity of vectors and their promising application as vaccines and cancer therapy agents, In: Y.Khudyakov (Ed.). Medicinal Protein Engineering. CRC Press, Taylor & Francis Group, Boca Raton London, New York, 2009, pp. 277-297.
17.      Plevka P, Kazaks A, Voronkova T, Kotelovica S, Dishlers A, Liljas L, Tars K. The structure of bacteriophage phiCb5 reveals a role of the RNA genome and metal ions in particle stability and assembly. J Mol Biol. 2009 Aug 21;391(3):635-47.  
18.      Rumnieks J, Ose V, Tars K, Dislers A, Strods A, Cielens I, Renhofa R. Assembly of mixed rod-like and spherical particles from group I and II RNA bacteriophage coat proteins. Virology. 2009 Sep 1;391(2):187-94.  
19.      Plevka P, Tars K, Liljas L. Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2. Protein Sci. 2009 Aug;18(8):1653-61.
20.      Balogh LM, Le Trong I, Kripps KA, Tars K, Stenkamp RE, Mannervik B, Atkins WM. Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals. Biochemistry. 2009 Aug 18;48(32):7698-704.
21.      Plevka P, Tars K, Liljas L. Structure and stability of icosahedral particles of a covalent coat protein dimer of bacteriophage MS2. Protein Sci. 2009 Aug;18(8):1653-61.
22.      Balogh LM, Le Trong I, Kripps KA, Tars K, Stenkamp RE, Mannervik B, Atkins WM. Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals. Biochemistry. 2009 Aug 18;48(32):7698-704.
23.      Ranka R., Brangulis K., Capligina V., Sondore V., Baumanis V. antigenicity of recombinant fibronectin binding protein fragments in Lyme disease. The FEBS Journal 2009, v.276, S1, 162-163
24.      Pelnena I., Pliss L., Baumanis V., Krumina A., Kucinskas V., Kasperaviciute D. The genetic component of the Baltic- speaking populations revealed by a wide set of Y chromosomal markers using phylogeographic approach. The FEBS Journal 2009, v.276, S1, 1a.
25.      Pliss L., Brakmanis A., Baumanis V., Krumina A., Rozane S., Sabule A.molecular study of genetic association between mitochondrial DNA heteroplasmy and ageing process among healthy unrelated Latvians. The FEBS Journal 2009, v.276, S1, 1b.
26.      F.Ianzini, E.A. Kosmacek, E.S. Nelson, E. Napoli, J. Erenpreisa, M. Kalejs, M. A. Mackey. Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation induced mitotic catastrophe. Cancer Res 2009, 69:2296-304.
27.      Tsarev I, Bungum M, Giwercman A, Erenpreisa J, Ebessen T, Ernst E, Erenpreiss J. Evaluation of male fertility potential by Toluidine Blue test for sperm chromatin structure assessment. Hum Reprod 2009, 24:1569-74.
28.      Erenpreisa J, Cragg MS, Salmina K, Hausmann M, Scherthan H. The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells. Exp Cell Res. 2009, 315:2593-603.  
29.      Ivanov A, Beers SA, Walshe CA, Honeychurch J, Alduaij W, Cox KL, Potter KN, Murray S, Chan CH, Klymenko T, Erenpreisa J, Glennie MJ, Illidge TM, Cragg MS. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J Clin Invest. 2009, 119:2143-59.  
30.      Erglis K., Ose V., Zeltins A., Cebers. Viscoelastisticity of the bacteriophage Pf1 network measured by magnetic microrheology. Magnetohydrodynamics, 2010, Vol. 46, 3–9.
31.      I.Sominskaya, D.Skrastiņa, A.Dislers, D.Vasiljev, M.Mihailova, V.Ose-Klinklava, Dz.Dreilina, P.Pumpens Construction and immunological evaluation of multivalent Hepatitis B core VLPs carryng HBV and HCV epitopes. Clinical and Vaccine Immunology, in revision.  
32.      Pjanova D, Molven A, Akslen LA, Streinerte B, Engele L, Azarjana K, and Heisele O. Identification of a CDK4 R24H mutation-positive melanoma family by analysis of early-onset melanoma patients in Latvia. Melanoma Res. 2009; 19:119-122.  
33.      Kalniņa I, Bruvere R, Zvagule T, Gabruseva N, Klimkane L,  Kirilova J,  Meirovics I,  Kizane G. Fluorescence Probe ABM and Estimation of Immune State in Patients with Different Pathologies (Review Article). J. of Fluorescence, 2009. DOI 10.1007/s10895-009-1515-6.
34.      Nelis, M., Esko, T., Magi, R., Zimprich, F., Zimprich, A., Toncheva, D., Karachanak, S., Piskackova, T., Balascak, I., Peltonen, L., Jakkula, E., Rehnstrom, K., Lathrop, M., Heath, S., Galan, P., Schreiber, S., Meitinger, T., Pfeufer, A., Wichmann, H. E., Melegh, B., Polgar, N., Toniolo, D., Gasparini, P., D'Adamo, P., Klovins, J., Nikitina-Zake, L., Kucinskas, V., Kasnauskiene, J., Lubinski, J., Debniak, T., Limborska, S., Khrunin, A., Estivill, X., Rabionet, R., Marsal, S., Julia, A., Antonarakis, S. E., Deutsch, S., Borel, C., Attar, H., Gagnebin, M., Macek, M., Krawczak, M., Remm, M. & Metspalu, A. (2009). Genetic structure of Europeans: a view from the North-East.  PLoS One. 2009;4(5):e5472. Epub 2009 May 8.
35.      Kontijevskis, A., Petrovska, R., Yahorava, S., Komorowski, J. & Wikberg, J. E. (2009). Proteochemometrics mapping of the interaction space for retroviral proteases and their substrates. Bioorg Med Chem 17, 5229-37.
36.      Kalnina, I., Kapa, I., Pirags, V., Ignatovica, V., Schioth, H. B. & Klovins, J. (2009). Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI. BMC Med Genet 10, 63.
37.      Shastry, A., Sedimbi, S. K., Rajalingam, R., Nikitina-Zake, L., Rumba, I., Wigzell, H. & Sanjeevi, C. B. (2008). Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians. Int J Immunogenet 35, 439-46.
 
Publikācijas vietējos zinātniskos un populārzinātniskos žurnālos:
38.      Sudmale G, Jansons J, Sominska I, Sondore V, Jēruma A, Arša F, Keišs J, Rozentāle B, Vīksna L, Pumpēns P. HCV genoma izmaiņas pretvīrusu terapijas gaitā hroniskas HCV infekcijas gadījumā (HCV genome changes during antiviral therapy of chronic HCV infection). 2009, RSU Raksti, pieņemts.
39.      Legzdiņa D, Keišs J, Sudmale G, Sominska I, Arša F, Davidjuka I, Sondore V, Vīksna L, Rozentāle B, Pumpēns P. HBV genoma mutācijas ar lamivudīnu ārstētiem B vīrushepatīta pacientiem Latvijā (Mutations of HBV genomes in lamivudine-treated hepatitis B patients in Latvia). 2009, RSU Raksti, pieņemts.  
40.      Ranka R., Capligina V., Brangulis K., Sondore V., Baumanis V. Cloning and expression of a recombinant immunogenic truncated BBK32 protein of Borrelia afzelli. Acta Universitatis Latviensis, 2009, vol.753,pp33-42.
41.      Pjanova D. Azarjana K, Čēma I, and Heisele O. Genetic alterations in melanoma development Proc. Latvian Acad. Sci. Section B. Vol.63 (2009), No. 3 (662), pp. 20-30.
42.      Kurjāne N, Brūvere R, Gabruševa N, Hagina E, Zvagule T, Jaunalksne I, Feldmane G, Volrāte A, Voskresenska N. Ageing and production of the cytokines in Chernobyl clean-up workers from Latvia. Procceedings of the Latvian Academy of Science, Section B, Vol. 63(2009). No.3 (662), pp.87-92.
43.      Ranka R., Capligina V., Brangulis K., Sondore V., Baumanis V. Cloning and expression of a recombinant immunogenic truncated BBK32 protein of Borrelia afzelli. Acta Universitatis Latviensis, 2009, vol.753,pp33-42.
44.      Pjanova D. Azarjana K, Čēma I, and Heisele O. Genetic alterations in melanoma development Proc. Latvian Acad. Sci. Section B. Vol.63 (2009), No. 3 (662), pp. 20-30.
45.      Kurjāne N, Brūvere R, Gabruševa N, Hagina E, Zvagule T, Jaunalksne I, Feldmane G, Volrāte A, Voskresenska N. Ageing and production of the cytokines in Chernobyl clean-up workers from Latvia. Proc. Latvian Acad. Sci. Section B, Vol. 63(2009). No.3 (662), pp.87-92.
46.      1.Jumutcs V, Zayakin P and Linē A. Applying ANN ensembles to melanomas –related diagnostics on cancer patients. Scientific Proceedings of Riga Technical University, Computer Science, 2008 (5): 100-108.
47.      2.E. Salna, K. Siliņa, J. Šaripova, A. Linē, N. Sjakste. Kvercetīna un kemferola ietekme uz iNOS ekspresiju kontroles un LPS inducēta iekaisuma gadījumā Wistar līnijas žurku aknās. LU Akadēmiskajais apgāds „LU Raksti. Medicīna", Nr 735., 2008. gads
48.      3.Linē A. Līcis N. One drug does not fit all. Doctus, 2005, 3:45-48 [in Latvian]
Date: 26.03.2010 at 14:33:38