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Jekaterina Erenpreisa (Read 28560 times)
Jekaterina Erenpreisa
16.03.2007 at 14:50:42
Laboratory Cell Biology
Latvian Biomedical Research and Study Centre, Riga

Chief: Jekaterina Erenpreisa

Jekaterina Erenpreisa, Dr.h.m
Leading Researcher,
Member Latvian Academy of Sciences
E-mail: katrina@biomed.lu.lv  
Basic research:

Mechanisms of resistance of malignant tumours to genotoxic therapy.  
The research on the role of induced endopolyploidy (giant cells) in genotoxic resistance and survival of p53-function-deficient tumour cell lines in collaboration with Southampton University has been started in 1998. These cells were shown to have advantage in repair of severe DNA damage and return to diploidy and mitosis. Illegitimate activation of the meiosis-similar program associated with reduction divisions of giant tumour cells was found. Together with Dr. Mark S Cragg, a cancer cell life-cycle hypothesis has been suggested postulating trigger between replicative cell senescence and renewal of tumour (stem?) cells occurring through cycling endopolyploidy, an alternative survival pathway of mitotic catastrophe (see the scheme below). Currently, studies on regulation of embryonic transactivation network and its relationship with senescence program in this system are carried out.  
Publications in basic cancer research:  
   1. Polyploid giant cells provide a survival mechanism for p53 mutant cells after DNA damage. (Illidge T., Cragg M., Fringe B., Olive P., Erenpreisa Je.)  Cell Biol. Int., 2000, 24,621-633.
   2. Release of mitotic descendants by giant cells from irradiated Burkitt lymphoma cell lines. (Erenpreisa Je., Cragg M., Fringes B., Sharakhov I., Illidge T.M.)  Cell Biol. Int. 2000, 24,635-648.
   3. Jānis Oļģerds Ērenpreiss and his theory of carcinogenesis. (Erenpreisa Je., Dalmane A., Erenpreiss Ju.)  Acta Medico-Historica Rigensia, Riga, 2000, Vol.V, p.281-285.
   4. “Tamed” chaos in embryonal development and carcinogenesis: a holistic view. (Erenpreisa Je.) Proc. Latv. Acad. Sci., 2000, 54, Nr ½: 1-8 .
   5. Mitotic death: a mechanism of survival? A review. (Erenpreisa Je., Cragg MS.)  Cancer Cell Int 2001, 1,1-7.
   6. Endopolyploid tumour cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks. (Ivanov A., Cragg M., Erenpreisa Je., Emzinsh D., Lukman H., Illidge TM)  J.Cell Sci, 2003, 116:4095-4106. http://bmc.biomed.lu.lv/site/common/Attachments/JCS_2003.pdf
   7. Cancer/testis antigenes and ploidy cycles. A review with brain storming. (Kalejs M and Erenpreisa Je).Cancer Cell Int 2005, 5:4 (online).
   8. Segregation of genomes in polyploid tumour cells following mitotic catastrophe. (Erenpreisa J, Kalejs M, Ianzini F, Kosmacek EA, Mackey MA, Emzinsh D, Cragg MS, Ivanov A, Illidge TM). Cell Biol Int, 2005, 29: 1005-1011.
   9. Mitotic catastrophe and endomitosis in tumour cells: An evolutionary key to a molecular solution. (Erenpreisa Je, Kalejs M, Cragg M). Cell Biol Int, 2005, 29: 1012-1018.
  10. Endopolyploidy in development and cancer; “survival of the fattest?” (editorial) (Erenpreisa J and Wheatley D).  Cell Biol Int 2005, 29: 981-982.
  11. Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult          and the induction of mitotic catastrophe. (Kalejs M, Ivanov A, Plakhins G, Cragg MS, Emzins Dz , Illidge TM, Erenpreisa Je.)  BMC Cancer 2006, doi:10.1186/1471-2407-6-6 http://bmc.biomed.lu.lv/site/common/Attachments/BMC_Cancer.pdf  
  12. Cancer: A matter of life-cycle? A mini-review. (Erenpreisa J and Cragg MS) Cell Biol Int 2007, 31: 1507-1510.
  13. Life-cycle features of tumour cells. (Erenpreisa J and Cragg MS)  In: P. Pontarotti (ed), Evolutionary Biology from Concept to Application, Springer Verlag, Berlin-Heidelberg, 2008, Chapter 4, pp. 61-7.
  14. Image analysis of DNA repair and apoptosis in tumor cells with differing sensitivity to DNA damage. (Ivanov A, Ivanova M, Erenpreisa J, Gloushen SV, Freivalds T, Cragg MS), in: Alexei Katashev, Yuri Dekhtyar, Janis Spigulis (Eds.) 14th Nordic-Baltic Conference on Biomedical Engineering (NBS) Proceedings Vol. 20, pp. 524–527.  Springer-Verlag Berlin Heidelberg 2008. www.springerlink.com/index/q01u279103875026.pdf
  15.  Endopolyploidy in irradiated p53-deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora-B kinase. (Erenpreisa J, Ivanov A, Wheatley SP, Kosmacek EA, Ianzini F, Anisimov AP, Mackey M, Davis PJ, Plakhins G, Illidge TM.) Cell Biol Int  2008, 32: 1044-1056. http://bmc.biomed.lu.lv/site/common/Attachments/CBI_AurB_2008.pdf  
  16. Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation induced mitotic catastrophe. (F. Ianzini, E.A. Kosmacek, E.S. Nelson, E. Napoli, J. Erenpreisa, M. Kalejs, M. A. Mackey). Cancer Res 2009, 69:2296-304. http://bmc.biomed.lu.lv/site/common/Attachments/CancerRes_2009.pdf  
  17. The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells (Erenpreisa J, Cragg MS, Salmina K, Hausmann M, Scherthan H.) Exp Cell Res. 2009, 315:2593-603. http://bmc.biomed.lu.lv/site/common/Attachments/ECR_2009_001.pdf  
  18. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells ( Ivanov A, Beers SA, Walshe CA, Honeychurch J, Alduaij W, Cox KL, Potter KN, Murray S, Chan CH, Klymenko T, Erenpreisa J, Glennie MJ, Illidge TM, Cragg MS) J Clin Invest. 2009, 119:2143-59. http://www.jci.org/articles/view/37884  
  19. Kristine Salmina, Eriks Jankevics, Anda Huna, Dmitry Perminov, Ilze Radovica,
Tetyana Klymenko, Andrey Ivanov, Elina Jascenko, Harry Scherthan,
Mark Cragg, Jekaterina Erenpreisa (2010) Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells. Exp Cell Res 316:2099- 2112.
  20. Erenpreisa Je and Cragg MS (2010) MOS, aneuploidy and the ploidy cycle of cancer cells.
Oncogene 29:5447-5451
Applied research in sperm chromatin structure:
   1. Comparative study of cytochemical  tests for sperm DNA integrity. (Erenpreiss J., Bars J., Lipatnikova V., Erenpreisa J., Zalkalns J.) J.Androl., 2001, 22, 45-53.
   2. Effect of leukocytospermia on sperm DNA integrity: A negative effect in abnormal semen samples. (Erenpreiss J., Hlevicka S., Zalkalns, Erenpreisa Je.)  J. Androl., 2002, 23,717-723.
   3. Toluidine blue test for sperm DNA integrity and elaboration of image cytometry algorithm. (Erenpreisa J., Erenpreiss J., Freivalds T., Slaidina M., Krampe R., Butikova J., Ivanov A., Pjanova D.) Cytometry, 2003, 52A, 19-27.
   4. Toluidine blue cytometry test for sperm DNA conformation: comparison with the flow cytometric sperm chromatin structure and TUNEL assays. (Erenpreiss J, Jepson K, Giwercman A, Tsarev I, Erenpreisa J, Spano M). Hum Reprod. 2004, 19:2277-82
   5. Sperm chromatin structure and male fertility: biological and clinical aspects. (Erenpreiss J, Spano M, Erenpreisa J, Bungum M, Giwercman A) Asian J. Androl 2006, 8:11-29.
   6. Evaluation of male fertility potential by Toluidine Blue test for sperm chromatin structure assessment. (Tsarev I, Bungum M, Giwercman A, Erenpreisa J, Ebessen T, Ernst E, Erenpreiss J.) Hum Reprod 2009, 24:1569-74.
sperm chromatin structure:
   7. Saori Sato, Shinya Matsumoto, Talivaldis Freivalds, Jekaterina Erenpreisa (2010) Consideration on the Metachromatic Spectra of Toluidine Blue Dimers Formed on DNA Oligomers. Bull. Chem. Soc. Jpn. Vol. 83, No. 10, 1216–1222.

Kristine Salmin’a – PhD student,  

Igor Tsarev – PhD student,  

Anda Huna – PhD student,  

Dmitry Perminov – BSc biol,
doing master degree project.  

Dr. Mark Steven Cragg (Southampton University), Dr. Andrey Ivanov, PhD (Beatson Inst.,Glazgow), Prof. Timothy M. Illidge (Paterson Cancer Research Institute, Manchester), Prof. Harry Scherthan (Inst. F. Radiobiologie der Bundeswehr, Munich), Prof. Michael Hausmann (Institut f. Physik, Heidelberg), Prof. Alim Anisimov (Far-East University, Vladivostok), Dr. Fiorenza Ianzini and Prof. Michael A MacKey (Iowa University), Prof. Alexander Giwercman (Lund University), Dr. Juris Erenpreiss (Riga Stradins University).

Prof. Mark Steven Cragg
Southampton University

Dr. Andrey Ivanov
PhD Beatson Inst.,Glazgow

Dr. Juris Erenpreiss
Riga Stradins University

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